AmnioMatrix™
Cryopreserved Multipotential Structural Tissue Matrix
An allograft tissue of live, viable cells for use as an in vivo wound covering
AmnioMatrix™ is derived from prescreened, live, healthy donors and procured during childbirth. It is then cryopreserved to provide viable human tissue for clinical use, all without use of a third-party tissue bank. AmnioMatrix™ has been developed from human amnion for use as an in vivo wound covering. In contrast, most human tissue products are derived from cadavers and processed by third-party tissue banks.
In the body of an expectant mother, amniotic membrane, fluid and cells act as a biologic system whose primary function is to (i) protect the fetus; and (ii) aid in fetal growth and development in vivo.As a liquid allograft, AmnioMatrix™ retains this protective function as a wound covering by acting as a tissue matrix for use in filling soft tissue defects, bone voids or as an anti-inflammatory wound covering.
Physicians have used amniotic tissue and fluid for over a century as a biologic dressing in a broad range of therapeutic applications.It has been generally recognized as a versatile wound covering with published clinical results cited extensively in medical and scientific literature.
An Abundant Source of Collagen
A cryopreserved structural tissue matrix derived from amniotic membrane and fluid that has been developed for clinical use to fill soft tissue defects or as an anti-inflammatory wound covering. Amniotic tissue is an abundant source of collagen that provides an extracellular matrix to act as a natural scaffold for cellular attachment in the body.
Collagen Facilitates Cell Migration and Proliferation
Collagen provides a structural tissue matrix that facilitates, among other things, cell migration and proliferation in vivo. Interstitial collagens (types I and II) form parallel bundles that provide the mechanical integrity of the membrane while collagens type V and VI form filamentous connections between interstitial collagens and the epithelial basement membrane.
Amnion Processing Preserves "Micro-Scaffold" Structure
AmnioMatrix™ was developed using a proprietary technique that morselizes the amnion in an effort to preserve its structural properties in an injectable form. This “micro-scaffold” created by the morselized tissue matrix includes the proteins, carbohydrates, lipids, hyaluronic acid, growth factors, and other chemical compounds naturally present in amniotic fluid and tissue to provide an in vivo wound covering that is derived from those components essential for fetal growth and development.
Presence of Live, Viable Cells
In addition to its structural properties, amniotic fluid derived stem cells have been shown to be broadly multipotent, capable of differentiating into adipogenic, osteogenic, myogenic, endothelial, neurogenic and hepatic cell lineages. While the primary function of AmnioMatrix™ is to provide a structural tissue matrix to fill, cover and protect the wound, the presence of viable cells in the product may provide ancillary clinical benefits by enhancing the body’s natural regenerative process.
AMNIOMATRIX™ DOES NOT REQUIRE FETAL SACRIFICE;
RECOVERY IS PERFORMED WITH MATERNAL CONSENT DURING LIVE BIRTH.
“Human amniotic membrane proved to be a versatile and useful temporary biologic dressing in studies involving [hundreds of patients for nearly 100 years.] Wounds, both traumatic and nontraumatic in origin, responded to a protocol that allowed coverage of tissues as diverse as exposed bowel, pleura, pericardium, blood vessels, tendon, nerve and bone…Wounds unresponsive to usual therapeutic measures responded to membrane application. Human amniotic membrane dressings are therefore a useful adjunct in the care of the complicated wound.” Joseph S. Gruss, et al., Human amniotic membrane: a versatile wound dressing, CMA JOURNAL/MAY 20, VOL. 118, p. 1237 (1978).
FOR HOMOLOGOUS USE ONLY